Key result
Pregnancy in spontaneously hypertensive rats is linked to increased heart rate without worsening blood pressure.
Why the study?
The effects of pregnancy on blood pressure, heart rate, and sympatho-adrenal activity in spontaneously hypertensive rats were unclear.
Does pregnancy affect blood pressure, heart rate, and sympatho-adrenal activity in spontaneously hypertensive rats?
Population
Non-pregnant and term-pregnant SP-SHR, SHR, and WKY female rats
Comparison
Pregnant vs non-pregnant females
Design
Preclinical experimental study
Authors
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Supports SHR as model for pregnancy hemodynamics; leaves open translation to human chronic hypertension.
Does pregnancy affect blood pressure, heart rate, and sympatho-adrenal activity in spontaneously hypertensive rats?
p-value: p=<0.05
Pregnancy in spontaneously hypertensive rats increases heart rate without exacerbating blood pressure or sympatho-adrenal activity, providing a potential experimental model for chronic hypertension in pregnancy.
McCarty et al. (1978) studied Hypertension. Pregnancy vs. Non-pregnant state was evaluated on Blood pressure, heart rate and plasma catecholamine levels (p=<0.05). Pregnancy in spontaneously hypertensive rats was associated with an increase in heart rate (P<0.05) but no further increases in blood pressure or circulating catecholamines compared to controls.