What is the clinical evidence from this study?

Study design: RCT. Population: Healthy volunteers (n=10). Intervention: Oral glucose + sodium chloride vs. 75 grams glucose alone. Primary outcome: Postprandial GLP-1 plasma concentration.

What question did this study set out to answer?

To determine whether postprandial plasma concentrations of GLP-1 and other gut hormones respond selectively to oral sodium chloride intake during a glucose challenge.

August 1, 2020Physiological ReportsOpen Access

Increased oral sodium chloride intake in humans amplifies selectively postprandial GLP‐1 but not GIP, CCK, and gastrin in plasma

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Key result

Adding 6 grams of oral sodium chloride to a 75-gram glucose load selectively amplified postprandial GLP-1 plasma concentrations compared to glucose alone in healthy men.

Why the study?

To investigate the hypothesis that postprandial GLP-1 plasma concentration is sensitive to the sodium content in a meal as part of a gut-kidney axis for natriuresis.

Does the addition of oral sodium chloride to a glucose load increase postprandial GLP-1 plasma concentrations in healthy males?

Key Points

To determine whether postprandial plasma concentrations of GLP-1 and other gut hormones respond selectively to oral sodium chloride intake during a glucose challenge.
Randomized crossover study in 10 lean healthy male participants following a 4-day fixed sodium intake and 12-hour fast.
Collected arterial blood samples at 10–20 minute intervals for 140 minutes after an oral load of 75 g glucose plus 6 g NaCl versus 75 g glucose alone.
Arterial GLP-1 concentrations were significantly higher at 40–80 minutes following glucose plus NaCl compared to glucose alone, accompanied by significantly lower angiotensin II levels at 60–80 minutes.
Postprandial concentrations of GIP, CCK, gastrin, glucose, insulin, C-peptide, renin, aldosterone, and natriuretic peptides did not differ between the two test days.

Study Design

Type

RCT (n=10)

Randomization

Random order

Structured PICO

Does the addition of oral sodium chloride to a glucose load increase postprandial GLP-1 plasma concentrations in healthy males?

Population

10 lean healthy male participants examined in a randomized crossover design to assess postprandial hormone responses over 140 minutes.

Intervention

75 grams of oral glucose + 6 grams of oral sodium chloride (NaCl) load

Comparator

75 grams of oral glucose alone

Outcome

Postprandial arterial GLP-1 plasma concentration over 140 minsurrogate

Adding sodium chloride to an oral glucose load selectively amplifies postprandial GLP-1 secretion, suggesting GLP-1's role in an acute feed-forward mechanism for natriuresis.

Discussion

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Implication

Suggests a physiological link between acute sodium intake and GLP-1 secretion.

Cite This Study

Asmar et al. (2020) conducted an RCT in Healthy volunteers (n=10). Oral glucose + sodium chloride vs. 75 grams glucose alone was evaluated on Postprandial GLP-1 plasma concentration. Adding 6 grams of oral sodium chloride to a 75-gram glucose load selectively amplified postprandial GLP-1 plasma concentrations compared to glucose alone in healthy men.

synapsesocial.com/papers/6a8f07073bd771695fcd8013 https://doi.org/10.14814/phy2.14519

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Increased oral sodium chloride intake in humans amplifies selectively postprandial GLP‐1 but not GIP, CCK, and gastrin in plasma

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Increased oral sodium chloride intake in humans amplifies selectively postprandial GLP‐1 but not GIP, CCK, and gastrin in plasma

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

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