Key result
Prognostic nomograms incorporating age, tumor size, stage, and tumor site predicted overall and cancer-specific survival in angiosarcoma patients with C-indices of 0.666 and 0.654, respectively.
Why the study?
This study was designed to establish and validate reliable nomograms for predicting overall and cancer-specific survival in patients with angiosarcoma.
Observational (n=785)
Yes
Effect estimate: C-indices of 0.666 for OS and 0.654 for CSS
Newly developed nomograms using SEER data provide moderate predictive accuracy for 3- and 5-year overall and cancer-specific survival in patients with angiosarcoma.
Provides moderate prognostic utility for angiosarcoma survival; leaves open the need for prospective validation before.
OBJECTIVE: This study was designed to establish and validate promising and reliable nomograms for predicting the survival of angiosarcoma (AS) patients. METHODS: The Surveillance, Epidemiology, and End Results database was queried to collect the clinical information of 785 AS patients between 2004 and 2015. Data were split into a training cohort (n = 549) and a validation cohort (n = 236) without any preference. Univariate Cox and multivariate Cox regression analyses were performed to analyze the clinical parameters. Independent prognostic factors were then identified. Two nomograms were constructed to predict overall survival (OS) and cancer-specific survival (CSS) at 3 and 5 years. Finally, the models were evaluated using concordance indices (C-indices), calibration plots, and decision curve analysis (DCA). RESULTS: Based on the inclusion and exclusion criteria, 785 individuals were included in this analysis. Univariate and multivariate Cox regression analyses revealed that age, tumor size, and stage were prognostic factors independently associated with the OS of AS. Tumor site, tumor size, and stage were associated with the CSS of AS. Based on the statistical results and clinical significance of variables, nomograms were built. The nomograms for OS and CSS had C-indices of 0.666 and 0.654, respectively. The calibration curves showed good agreement between the predictive values and the actual values. DCA also indicated that the nomograms were clinically useful. CONCLUSION: We established nomograms with good predictive ability that could provide clinicians with better predictions about the clinical outcomes of AS patients.
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Liu et al. (2021) conducted an observational in Angiosarcoma (n=785). Prognostic nomograms was evaluated on Overall survival (OS) and cancer-specific survival (CSS) at 3 and 5 years (C-indices of 0.666 for OS and 0.654 for CSS). Prognostic nomograms incorporating age, tumor size, stage, and tumor site predicted overall and cancer-specific survival in angiosarcoma patients with C-indices of 0.666 and 0.654, respectively.
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