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October 1, 1998Journal of Biological ChemistryOpen Access

The Mechanism of Inhibition of Topoisomerase IV by Quinolone Antibacterials

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Authors

AKArkady KhodurskyUniversity of California SystemNCNicholas R. CozzarelliUniversité Paris-Sud

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Khodursky et al. (1998) studied this question.

synapsesocial.com/papers/6a8f0bedc2a8a91e7c3bf180https://doi.org/10.1074/jbc.273.42.27668
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cloning and primary structure of <i>Staphylococcus aureus</i> DNA topoisomerase IV: a primary target of fluoroquinolones1994 · 378 citations
  2. 2Mechanism of action of nalidixic acid: Purification of <i>Escherichia coli nalA</i> gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme1977 · 789 citations
  3. 3Quinolone-resistant mutants of escherichia coli DNA topoisomerase IV parC gene1996 · 88 citations
  4. 4Repair of DNA double-strand breaks in Escherichia coli cells requires synthesis of proteins that can be induced by UV light.1981 · 40 citations
  5. 5Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae1996 · 442 citations