Key result
Three murine anti-human beta-interferon monoclonal antibodies were isolated following adoptive transfer of immune spleen cells, defining two epitopes on IFN-beta.
Adoptive transfer in irradiated mice successfully facilitated the isolation of monoclonal antibodies that define functional epitopes on human beta-interferon.
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May guide preclinical anti-IFN-beta antibody development; leaves open human translation.
Three murine anti-human beta-interferon (IFN-beta) monoclonal antibodies have been isolated following adoptive transfer of immune spleen cells. Adoptive transfer was used to increase the specific efficiency of the fusion. These antibodies have been used to define two epitopes on IFN-beta; the antiviral, antiproliferative, and immunomodulatory effects of IFN-beta are associated with one of these epitopes.
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Thompson et al. (1986) studied this question. Adoptive transfer of immune spleen cells was evaluated on Isolation of murine anti-human beta-interferon monoclonal antibodies and definition of epitopes. Three murine anti-human beta-interferon monoclonal antibodies were isolated following adoptive transfer of immune spleen cells, defining two epitopes on IFN-beta.
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