Key result
Three murine anti-human beta-interferon monoclonal antibodies were isolated following adoptive transfer of immune spleen cells, defining two epitopes on IFN-beta.
Population
Irradiated mice
Design
Preclinical
Authors
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May guide preclinical anti-IFN-beta antibody development; leaves open human translation.
Adoptive transfer in irradiated mice successfully facilitated the isolation of monoclonal antibodies that define functional epitopes on human beta-interferon.
Thompson et al. (1986) studied this question. Adoptive transfer of immune spleen cells was evaluated on Isolation of murine anti-human beta-interferon monoclonal antibodies and definition of epitopes. Three murine anti-human beta-interferon monoclonal antibodies were isolated following adoptive transfer of immune spleen cells, defining two epitopes on IFN-beta.
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