Key result
GHSR C3286 > T and TGFB2 T(-640) > C single nucleotide polymorphisms were associated with growth and body composition traits in broiler chickens.
Observational
GHSR and TGFB2 SNPs are associated with growth and body composition traits in broiler chickens, suggesting their potential utility as genetic markers for selective breeding.
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Supports GHSR/TGFB2 SNPs as candidate markers for broiler selection; leaves open replication and functional validation before breeding application.
Growth hormone secretagogue receptor (GHSR) modulates many physiological processes by binding to its ligand, as well as transforming growth factor-beta 2 (TGFB2) regulates cell growth and development in animals and, therefore, are candidate genes for performance in chickens. In the current study, single nucleotide polymorphisms of GHSR C3286 > T and TGFB2 T(-640) > C were genotyped in sire and dam lines of a broiler chicken to evaluate the association with the growth and body composition traits. Least squares means analysis showed that the GHSR C3286 > T SNP was significantly (P < 0.01) associated with growth (DFI and ADG) and body composition traits (AFW and %AFW). In addition, the TGFB2 T(-640) > C SNP was associated with ADG (P < 0.05) and DFI and body composition traits (DW, LBW, BAKWT, %BMW, %HNDWT and %CW) (P < 0.01). Significant associations of the single nucleotide polymorphisms (SNPs) on the traits reported in the present study might be the distinct usage of codons in avian, or relating to an enhancer element and modulating the expression of the gene in chicken. The data indicated that these SNPs could be valuable genetic elements for selection of chickens for better performance in the population.
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Niarami et al. (2013) conducted an observational in Growth and body composition traits in broiler chickens. GHSR C3286 > T and TGFB2 T(-640) > C single nucleotide polymorphisms was evaluated on Growth (DFI and ADG) and body composition traits (p=<0.01). GHSR C3286 > T and TGFB2 T(-640) > C single nucleotide polymorphisms were associated with growth and body composition traits in broiler chickens.
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