Key result
Elevated glucose and altered myocardial glucose metabolism contribute to diabetic cardiomyopathy by inducing aberrant protein O-GlcNAcylation, which impairs cardiac contractility and mitochondrial function.
Altered glucose metabolism and chronic hyperglycemia directly contribute to the pathogenesis of diabetic cardiomyopathy via alternative metabolic pathways, highlighting potential novel therapeutic targets beyond systemic glycemic control.
No takes yet. Share an insight, caveat, or question.
Highlights O-GlcNAcylation as potential target in diabetic cardiomyopathy; leaves open clinical efficacy pending prospective trials.
Brahma et al. (2017) conducted a review in Diabetic Cardiomyopathy. Hyperglycemia was evaluated. Elevated glucose and altered myocardial glucose metabolism contribute to diabetic cardiomyopathy by inducing aberrant protein O-GlcNAcylation, which impairs cardiac contractility and mitochondrial function.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: