Key result
Immunologic mechanisms, including autoantibody production and allogenic transformation of myocardial cell membranes, play a central role in the pathogenesis of various forms of heart disease.
Highlights the shared immunologic mechanisms, specifically autoantibody production and immunoregulatory failure, underlying various forms of heart disease.
May support immunomodulatory research in heart disease; leaves open confirmation in prospective trials.
All forms of heart disease, whether caused by streptococcus group A, aseptic heart injury, virus, hypersensitivity, autoimmune conditions, or graft-versus-host reactions, have in common allogenic transformation of the myocardial cell membrane and production of multifunctional autoantibodies, in addition to cause-specific antibodies, some of which cross-react with heart tissue. The outcome of this immunologic insult depends on the ability of the host's immunoregulatory mechanisms to dispose swiftly of the offending antigen and antibody or their complexes. Heart disease often results when these mechanisms, exemplified here, are not intact or when they function inappropriately in genetic or acquired settings and in varying haplotype frames.
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S. DeCarvalho (1982) conducted a review in Heart disease. Immunologic mechanisms, including autoantibody production and allogenic transformation of myocardial cell membranes, play a central role in the pathogenesis of various forms of heart disease.
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