Key result
An 11-month-old female infant developed autoimmune hepatitis and atopic dermatitis 6 months post-hematopoietic stem cell transplantation, with positive tests exclusively for Teno Torque virus.
Case Report (n=1)
This case report suggests a potential association between Teno Torque virus and autoimmunity following hematopoietic stem cell transplantation.
Single case links Torque Teno virus to post-HSCT autoimmunity in an infant; leaves open causal role pending prospective validation.
Teno Torque virus, member of the family of Anelloviridae, has been associated with many autoimmune diseases such as idiopathic hepatitis, systemic lupus erythematosus, and multiple sclerosis. Its viral load tends to be higher in the bone marrow and in tissues with high turnover rate. We report here a case of an 11-month-old infant affected by acute myeloid leukemia who underwent hematopoietic stem cell transplantation, and after 6 months had autoimmune hepatitis and atopic dermatitis. Extremely high-cytokine IP-10 and eotaxin levels were found in her sera, and serological tests and RT-PCR for viruses showed positive results exclusively for Teno Torque virus.
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Maximova et al. (2014) conducted a case report in Acute myeloid leukemia post-hematopoietic stem cell transplantation (n=1). Teno Torque virus infection was evaluated on Development of autoimmune hepatitis and atopic dermatitis. An 11-month-old female infant developed autoimmune hepatitis and atopic dermatitis 6 months post-hematopoietic stem cell transplantation, with positive tests exclusively for Teno Torque virus.
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