Key result
Catheter ablation significantly reduced the Tp-e interval (from 86.6 to 80.6 ms, p=0.021) and Tp-e/JT ratio (from 0.307 to 0.279, p=0.001) in patients with Wolff-Parkinson-White syndrome.
Why the study?
Preexcitation in Wolff Parkinson White syndrome may preclude accurate measurement of ventricular repolarization by QT, prompting assessment of Tp-e and Tp-e/JT before and after ablation.
Does catheter ablation reduce Tp-e interval and Tp-e/JT ratio in patients with symptomatic Wolff Parkinson White syndrome?
Observational (n=50)
Single-blind
No
Does catheter ablation reduce Tp-e interval and Tp-e/JT ratio in patients with symptomatic Wolff Parkinson White syndrome?
Catheter ablation in patients with WPW syndrome significantly reduces the Tp-e interval and Tp-e/JT ratio, suggesting a decrease in the dispersion of ventricular repolarization.
Suggests ablation may reduce arrhythmogenic ventricular repolarization dispersion in WPW syndrome; leaves open.
Aim: Tp-e and Tp-e/QT are novel markers of ventricular repolarization. However, preexcitation in Wolff Parkinson White (WPW) syndrome may preclude accurate measurement of repolarization as assessed by the QT. We aimed to research the assessment of Tp-e and Tp-e/JT before and after ablation in WPW. Material and Method: We enrolled 50 consecutive patients with symptomatic WPW syndrome who underwent catheter ablation of their accessory pathways for treatment. All of the patients were successfully ablated. ECGs were performed before the procedure and repeated after the ablation procedure. Results: Tp-e (86.6±16.2 vs 80.6±12.5; p=0.021) and Tp-e(c) (96.7±18.9 vs 88.3±11.2; p=0,005) showed a significant decrease after the procedure. Tp-e/JT (0.307±0.053 vs 0.279±0.040; p=0.001) and Tp-e/JT(c) (0.276±0.048 vs 0.255±0.045; p=0.009) showed a significant decrease after the procedure. There was a significant association between ERP and before procedure Tp-e (c) (r=- 0.370, p=0.008) and Tp-e/JT (r=- 0.371, p=0.008). Conclusion: This study demonstrated that Tp-e and Tp-e/JT were significantly diminished in WPW after the ablation.
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Akdi et al. (2022) conducted an observational in Wolff Parkinson White (WPW) syndrome (n=50). Catheter ablation vs. Pre-ablation baseline was evaluated on Tp-e interval (ms) (p=0.021). Catheter ablation significantly reduced the Tp-e interval (from 86.6 to 80.6 ms, p=0.021) and Tp-e/JT ratio (from 0.307 to 0.279, p=0.001) in patients with Wolff-Parkinson-White syndrome.
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