Key result
Mesalazine administration in a 26-year-old male with ulcerative colitis induced acute myopericarditis that resolved upon discontinuation and recurred rapidly upon re-challenge.
Why the study?
Does mesalazine cause myopericarditis in patients with ulcerative colitis?
Case Report (n=1)
No
Does mesalazine cause myopericarditis in patients with ulcerative colitis?
Mesalazine can induce acute myopericarditis in patients with inflammatory bowel disease, which resolves upon discontinuation and recurs upon re-challenge.
Consider mesalazine in myopericarditis differential for ulcerative colitis; single case leaves open need for confirmation.
Inflammatory bowel disease (IBD) is considered as a dysregulated immune mediated disease. Pericarditis in IBD is a very rare disease both as an extra-intestinal manifestation of IBD and an adverse reaction of therapeutic drug for IBD such as mesalazine or sulfasalazine. A 26-year-old IBD male patient who had been taking mesalazine regularly for about 1 month was referred to our hospital because of fever, chest discomfort, and abnormal electrocardiographic findings. The patients was diagnosed as acute myopericarditis, and recovered after cessation of mesalazine using steroid and aspirin. When mesalazine was re-medicated some days after discharge, he suffered from myopericarditis again. Subsequently, myopericarditis was resolved just after cessation of mesalazine again. These findings suggest that the development of myopericarditis is caused by mesalazine.
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Park et al. (2012) conducted a case report in Ulcerative Colitis (n=1). Mesalazine was evaluated on Development of myopericarditis. Mesalazine administration in a 26-year-old male with ulcerative colitis induced acute myopericarditis that resolved upon discontinuation and recurred rapidly upon re-challenge.
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