Key result
Apical hypertrophic cardiomyopathy was associated with impaired coronary flow reserve of penetrating intramyocardial coronary arteries compared to normotensive controls and hypertensive patients.
Why the study?
Does high-frequency transthoracic echocardiography demonstrate impaired coronary flow reserve of penetrating intramyocardial coronary arteries in patients with apical hypertrophic cardiomyopathy compared to controls?
Cross-Sectional (n=65)
No
Does high-frequency transthoracic echocardiography demonstrate impaired coronary flow reserve of penetrating intramyocardial coronary arteries in patients with apical hypertrophic cardiomyopathy compared to controls?
High-frequency transthoracic echocardiography demonstrates that patients with apical hypertrophic cardiomyopathy have higher resting velocity, wider diameter, and more impaired coronary flow reserve in penetrating intramyocardial coronary arteries compared to controls.
Answers are grounded in this paper and cite their sources.
May support microvascular dysfunction in apical hypertrophic cardiomyopathy; hypothesis-generating and requires prospective validation before clinical adoption.
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Youn et al. (2004) conducted a cross-sectional in Apical hypertrophic cardiomyopathy (n=65). Apical hypertrophic cardiomyopathy vs. Normotensive subjects without hypertrophy and hypertensive subjects without hypertrophy was evaluated on Coronary flow reserve of penetrating intramyocardial coronary artery (PICA-CFR) (p=<0.005). Apical hypertrophic cardiomyopathy was associated with impaired coronary flow reserve of penetrating intramyocardial coronary arteries compared to normotensive controls and hypertensive patients.
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