Key result
Helicobacter pylori infection in dyspeptic subjects was associated with significantly higher urinary 8-iso-PGF2alpha and 11-dehydro-TXB2 excretion compared to uninfected controls.
Why the study?
Does H pylori eradication reduce lipid peroxidation and platelet activation in H pylori-positive dyspeptic subjects?
Population
78 otherwise healthy dyspeptic subjects
Comparison
H pylori eradication and selective… vs H pylori-negative dyspeptic subjects and…
Design
Cohort
Authors
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May promote atherothrombosis via oxidative stress and platelet activation; hypothesis-generating for eradication trials.
Observational (n=78)
Does H pylori eradication reduce lipid peroxidation and platelet activation in H pylori-positive dyspeptic subjects?
H pylori infection is associated with enhanced in vivo lipid peroxidation and platelet activation, which are reduced upon eradication, suggesting a potential mechanism for infection-related atherothrombosis.
Davı̀ et al. (2004) conducted an observational in Dyspepsia (n=78). Helicobacter pylori infection vs. H pylori-negative dyspeptic individuals was evaluated on Urinary 8-iso-PGF2alpha and 11-dehydro-TXB2 excretion. Helicobacter pylori infection in dyspeptic subjects was associated with significantly higher urinary 8-iso-PGF2alpha and 11-dehydro-TXB2 excretion compared to uninfected controls.
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