Why the study?
Intramyocardial inflammatory activity in HFpEF myocardial biopsies suggests inflammatory processes are predominantly systemic with compartment-specific patterns, closely related to extracardiac comorbidities.
Population
Patients with HFpEF (n=6), HFrEF (n=8), and healthy controls (n=7), plus an HFpEF mouse model
Comparison
HFpEF vs HFrEF vs healthy controls, and HFpEF mice with vs without nitro-oleic acid
Design
Translational single-cell and bulk RNA sequencing study with a parallel mouse model
Key result
Patients with HFpEF exhibited a distinct peripheral blood mononuclear cell transcriptional immune signature characterized by obesity-related cytokine signaling and mitochondrial-associated activity.
Authors
Loading...
Hypothesis-generating for targeted anti-inflammatory therapies in HFpEF; leaves open whether modulating.
Observational (n=21)
HFpEF is associated with a distinct, conserved systemic inflammatory transcriptional signature that may serve as a target for personalized interventions such as nitro-oleic acid.
Kneuer et al. (2025) conducted an observational in Heart failure with preserved ejection fraction (HFpEF) (n=21). Heart failure with preserved ejection fraction (HFpEF) vs. HFrEF and healthy controls was evaluated on Peripheral blood mononuclear cell transcriptional immune signature. Patients with HFpEF exhibited a distinct peripheral blood mononuclear cell transcriptional immune signature characterized by obesity-related cytokine signaling and mitochondrial-associated activity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: