Why the study?
How do serum insulin secretion, growth hormone responses, and serum lipid profiles compare between newly diagnosed African diabetic patients and healthy African controls?
Cross-Sectional (n=157)
No
How do serum insulin secretion, growth hormone responses, and serum lipid profiles compare between newly diagnosed African diabetic patients and healthy African controls?
Both diabetic and healthy Africans exhibit low insulin secretion—likely related to a diet high in unrefined carbohydrate (maize meal)—which accounts for the high rate of insulin-dependent diabetes (76%) and may explain the rarity of coronary heart disease in this population despite typical diabetic elevations in serum lipids and growth hormone.
Answers are grounded in this paper and cite their sources.
May explain high insulin-dependent diabetes rates in Africans; leaves open dietary links to low coronary disease despite typical lipid elevations.
The high proportion of unrefined carbohydrates (maize meal) in the diet of Africans could be responsible for their low insulin secretion. The consequent insulinopenia in the general African population may explain the comparative rarity of typical non-insulin dependent diabetes mellitus, and also the virtual absence of coronary heart disease. Changes in growth hormone secretion and in serum lipids, known to be associated with diabetes in Europeans, are also found in African patients.
No takes yet. Share an insight, caveat, or question.
Wicks et al. (1973) conducted a cross-sectional in Diabetes mellitus (n=157). Newly diagnosed diabetes mellitus in Africans vs. Healthy urban male African cleaners was evaluated on Fasting serum insulin and insulin response to oral glucose tolerance test and intravenous tolbutamide (p=<0.002).
Synapse has enriched 10 related papers. Consider them for comparative context: