Two generally applicable reagents for photoaffinity probes have been developed. They contain an m-nitrophenyl ether function with a trifluoromethyldiazirine side chain (photophore group), as well as a biotin tag for the identification of labeled proteins or peptides and either a free hydroxy or a squaramide group for the attachment of any suitably functionalized ligand which directs the reagent to the binding site of the target molecule (see picture).
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Daghish et al. (2002) studied this question.
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