Key result
Genomic and epidemiological evidence suggests voltage-gated calcium channel blockers may have therapeutic potential in psychiatry, encouraging the development of brain-selective agents.
Why the study?
To reappraise the psychiatric potential of calcium channel blockers given that voltage-gated calcium channels are risk genes and their use is linked to altered psychiatric outcomes.
Do calcium channel blockers alter psychiatric risks and outcomes in patients with psychiatric disorders?
Do calcium channel blockers alter psychiatric risks and outcomes in patients with psychiatric disorders?
Brain-selective calcium channel blockers may hold therapeutic potential for psychiatric disorders based on genomic and observational evidence.
We reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and outcomes. Third, research shows there is an opportunity for brain-selective CCBs, which are better suited to psychiatric indications.
No takes yet. Share an insight, caveat, or question.
Harrison et al. (2019) conducted a review in Psychiatric disorders. Voltage-gated calcium channel blockers was evaluated. Genomic and epidemiological evidence suggests voltage-gated calcium channel blockers may have therapeutic potential in psychiatry, encouraging the development of brain-selective agents.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: