What question did this study set out to answer?

To review the regulatory functions of microRNAs in tumorigenesis and evaluate evolving strategies and clinical applications for targeting them in cancer gene therapy.

January 9, 2017Open Access

Targeting MicroRNAs in Cancer Gene Therapy

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Authors

WJWeidan Ji BSBin Sun CSChangqing Su

Discussion

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Overview

Review reveals therapeutic targeting strategies for microRNAs in tumor models, highlighting their utility as oncogenic drivers and clinical targets.

Key Points

To review the regulatory functions of microRNAs in tumorigenesis and evaluate evolving strategies and clinical applications for targeting them in cancer gene therapy.
Narrative review synthesizing evidence on microRNA expression profiles across diverse cancer cell lines and tumor tissues.
Evaluation of mechanistic roles of microRNAs in biological processes including proliferation, survival, motility, and tumor development.
MicroRNAs exhibit extensive dysregulation across multiple tumor types, causally functioning as either oncogenes or tumor suppressors throughout various stages of malignant progression.
Therapeutic strategies directed at modulating aberrant microRNAs provide viable molecular targets to suppress tumor growth and enhance the efficacy of cancer treatment regimens.

Cite This Study

Ji et al. (2017) studied this question.

synapsesocial.com/papers/6a8f83ad76d63252939f9fa4 https://doi.org/10.20944/preprints201701.0046.v1

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January 9, 2017Open Access

Targeting MicroRNAs in Cancer Gene Therapy

View Full Paper

Ask AI

Bookmark

Authors

WJWeidan Ji BSBin Sun CSChangqing Su

Discussion

Member takes

Overview

Review reveals therapeutic targeting strategies for microRNAs in tumor models, highlighting their utility as oncogenic drivers and clinical targets.

Key Points

To review the regulatory functions of microRNAs in tumorigenesis and evaluate evolving strategies and clinical applications for targeting them in cancer gene therapy.
Narrative review synthesizing evidence on microRNA expression profiles across diverse cancer cell lines and tumor tissues.
Evaluation of mechanistic roles of microRNAs in biological processes including proliferation, survival, motility, and tumor development.
MicroRNAs exhibit extensive dysregulation across multiple tumor types, causally functioning as either oncogenes or tumor suppressors throughout various stages of malignant progression.
Therapeutic strategies directed at modulating aberrant microRNAs provide viable molecular targets to suppress tumor growth and enhance the efficacy of cancer treatment regimens.

Cite This Study

Ji et al. (2017) studied this question.

synapsesocial.com/papers/6a8f83ad76d63252939f9fa4 https://doi.org/10.20944/preprints201701.0046.v1

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