Key result
Methylphenidate blood levels showed no significant associations with clinical response in behavioral measures or laboratory tests of attention or activity.
Why the study?
Do methylphenidate blood levels correlate with clinical response in hyper-active children and normal adults?
Do methylphenidate blood levels correlate with clinical response in hyper-active children and normal adults?
Routine methylphenidate blood level determinations are unlikely to be useful in the clinical management of hyperactive children due to a lack of correlation with clinical response.
Answers are grounded in this paper and cite their sources.
Caution against routine methylphenidate TDM in hyperactive children; leaves open need for prospective exposure-response trials.
The clinical correlates of methylphenidate blood levels in hyper-active children and normal adults were examined in five studies. Although occasional correlations between blood levels and neuroendocrine response were noted within subjects along the pharmacokinetic time profile of the drug, no significant associations were found between blood levels and clinical response in behavioral measures or laboratory tests of attention or activity. It is unlikely that routine methylphenidate blood level determinations will become a part of the routine clinical management of hyperactive children.
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Gualtieri et al. (1984) conducted a review in Hyperactivity. Methylphenidate blood levels was evaluated on Clinical response in behavioral measures or laboratory tests of attention or activity. Methylphenidate blood levels showed no significant associations with clinical response in behavioral measures or laboratory tests of attention or activity.
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