Key result
Cardiovascular autonomic neuropathy in diabetic patients was associated with reduced gastric clearance compared to those without neuropathy (17.8 vs 29.5 markers per 6 hours; p<0.02).
Why the study?
Are gastrointestinal motility disorders associated with cardiovascular signs of autonomic neuropathy in patients with insulin-dependent diabetes mellitus?
Cross-Sectional (n=26)
Are gastrointestinal motility disorders associated with cardiovascular signs of autonomic neuropathy in patients with insulin-dependent diabetes mellitus?
Absolute Event Rate: 17.8% vs 29.5%
p-value: p=< 0.02
Cardiovascular autonomic neuropathy in diabetic patients is associated with widespread gastrointestinal motor dysfunction, suggesting a generalized autonomic neuropathy.
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May warrant GI evaluation in diabetics with cardiovascular autonomic neuropathy; leaves open causal direction and need for prospective validation.
Werth et al. (1992) conducted a cross-sectional in Insulin dependent diabetes mellitus (n=26). Cardiovascular autonomic neuropathy vs. Without cardiovascular autonomic neuropathy was evaluated on Mean gastric clearance of radioopaque markers per six hours (p=< 0.02). Cardiovascular autonomic neuropathy in diabetic patients was associated with reduced gastric clearance compared to those without neuropathy (17.8 vs 29.5 markers per 6 hours; p<0.02).
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