Key result
Classic antiepileptic drugs stabilize the fast-inactivated state of voltage-gated sodium channels, whereas novel agents like lacosamide stabilize the slow-inactivated state to treat epilepsy.
Classic anticonvulsants target the fast-inactivated state of voltage-gated sodium channels, while newer drugs like lacosamide and ranolazine target the slow-inactivated state, offering distinct therapeutic mechanisms.
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Distinguishes fast- versus slow-inactivation sodium channel targeting; leaves open extension to antiarrhythmic mechanisms.
Abdelsayed et al. (2013) conducted a review in Epilepsy. Anticonvulsants was evaluated. Classic antiepileptic drugs stabilize the fast-inactivated state of voltage-gated sodium channels, whereas novel agents like lacosamide stabilize the slow-inactivated state to treat epilepsy.