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August 25, 2026PLoS ONEOpen Access

Identification of candidate macrophage-ferroptosis crosstalk genes associated with immune infiltration in myocardial infarction: A bioinformatics analysis

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Key result

Bioinformatics analysis identifies 7 primary macrophage- and ferroptosis-related genes linked to MI.

Why the study?

Macrophage-mediated inflammation and ferroptosis-related stress responses are implicated in MI, but transcriptomic identification of macrophage- and ferroptosis-related candidate genes requires rigorous control of false-positive findings.

Population

Peripheral blood transcriptomic datasets GSE29532 and GSE48060 and AMI peripheral blood samples

Design

Bioinformatics analysis and RT-qPCR validation study

Authors

GWGuoqin WangZZZhulin ZhangGYGuanrui Yang

Discussion

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Overview

Hypothesis-generating for MI gene targets; leaves open validation and clinical translation.

Structured PICO

P
Population
Peripheral blood transcriptomic datasets (GSE29532 and GSE48060) and AMI peripheral blood samples for validation
E
Exposure
Bioinformatics analysis and RT-qPCR validation
O
Outcome
Identification of macrophage- and ferroptosis-related candidate genes (MFRDEGs)surrogate

This bioinformatics study identifies seven macrophage- and ferroptosis-related genes associated with immune infiltration in myocardial infarction, providing potential novel biomarkers or therapeutic targets.

Limitations

  • Small input gene set for GO enrichment analysis
  • Requires further validation in larger cohorts and mechanistic studies
  • small input gene set for GO enrichment
  • PPI analysis did not produce reliable interactions
  • requires further validation in larger cohorts and mechanistic studies

Cite This Study

Wang et al. (2026) studied Myocardial infarction. Macrophage- and ferroptosis-related transcriptional alterations was evaluated on Differentially expressed genes (DEGs). Bioinformatics analysis of transcriptomic datasets identified 213 differentially expressed genes, including seven primary macrophage- and ferroptosis-related genes associated with myocardial infarction.

synapsesocial.com/papers/6a8fae0db2cf76216e4a339bhttps://doi.org/10.1371/journal.pone.0356358
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