Why the study?
Manipulating macrophage M1/M2 phenotypic transition is a promising therapeutic strategy for tissue repair after myocardial infarction.
Does gene ablation of HIMF reduce myocardial infarct size and improve cardiac function in a mouse model of myocardial infarction?
Population
Mice (Himf -/- and HIMF flox/flox;Lyz2-Cre) with myocardial infarction and cultured macrophages
Comparison
HIMF gene ablation vs control/wild-type or HIMF expression
Design
Preclinical animal and in vitro mechanistic study
Authors
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HIMF ablation may aid post-MI repair in mice; leaves open whether targeting HIMF improves human outcomes.
Does gene ablation of HIMF reduce myocardial infarct size and improve cardiac function in a mouse model of myocardial infarction?
HIMF deletion promotes reparative M2 macrophage polarization and reduces infarct size after myocardial infarction, suggesting HIMF as a potential therapeutic target for myocardial repair.
Li et al. (2021) studied this question.
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