The study demonstrates that HSV-1 Vhs protein requires higher levels to mediate RNA degradation in primary neurons compared to other susceptible cells.
Neurons require higher Vhs levels for RNA degradation than other cells; leaves open relevance to HSV-1 latency and needs in vivo confirmation.
The virion host shutoff protein (Vhs) of herpes simplex virus type 1 induces destabilization of mRNA following infection. Our study of primary neurons from CD-1 mice demonstrates that vhs is functional in neurons but that more Vhs is required to mediate RNA degradation in neurons than in other susceptible cells.
No takes yet. Share an insight, caveat, or question.
Strand et al. (2004) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: