Key result
The herpes simplex virus virion host shutoff protein (vhs) induces mRNA decay that proceeds in a 5' to 3' direction in an in vitro assay system.
The study demonstrates that herpes simplex virus vhs protein induces mRNA decay in a 5' to 3' direction in vitro.
In vitro HSV vhs findings require cellular validation; leaves open in vivo mRNA decay role in pathogenesis.
The herpes simplex virus virion host shutoff protein (vhs) is an mRNA-specific RNase that contributes to shutoff of host protein synthesis. We show here that vhs-induced mRNA decay proceeds 5' to 3' in an in vitro assay system derived from rabbit reticulocyte lysate.
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Perez-Parada et al. (2004) studied this question. Herpes Simplex Virus vhs Protein vs. Control rabbit reticulocyte lysate was evaluated on Direction of RNA degradation. The herpes simplex virus virion host shutoff protein (vhs) induces mRNA decay that proceeds in a 5' to 3' direction in an in vitro assay system.
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