Why the study?
The determinants of pulmonary hypertension due to HFpEF have been poorly investigated in patients with cardiovascular diseases.
Do left atrial diameter, atrial fibrillation, and NT-proBNP predict the development of pulmonary hypertension in patients with HFpEF?
Do left atrial diameter, atrial fibrillation, and NT-proBNP predict the development of pulmonary hypertension in patients with HFpEF?
Electrical and anatomical remodeling of the left atrium (atrial fibrillation and left atrial diameter) are key predictors of pulmonary hypertension in patients with HFpEF.
Answers are grounded in this paper and cite their sources.
Associations in cross-sectional HFpEF-PH data warrant caution; leaves open causal links for prospective validation.
BACKGROUND: The determinants of pulmonary hypertension (PH) due to heart failure with preserved ejection fraction (HFpEF) have been poorly investigated in patients with cardiovascular diseases (CVD). METHODS: From July 1 2017 to March 31 2019, a total of 149 consecutive HFpEF patients hospitalized with CVD were enrolled in this prospective cross-sectional study. A systolic pulmonary artery pressure (PASP) > 35 mmHg estimated by echocardiography was defined as PH-HFpEF. Logistic regression was performed to establish predictors of PH in HFpEF patients. CONCLUSIONS: Two parameters associated with electrical and anatomical remodelling of the left atrium were related to the incidence of PH in HFpEF patients with CVD.
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Liu et al. (2020) studied this question.
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