January 1, 2006Cellular Physiology and Biochemistry

Ischemia Impairs the Association Between Connexin 43 and M3 Subtype of Acetylcholine Muscarinic Receptor (M3-mAChR) in Ventricular Myocytes

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Population

Ventricular myocytes from control and ischemic hearts

Comparison

Ischemia vs Control (non-ischemic) conditions

Design

Preclinical

Authors

PYPeng YueXinjiang Institute of Materia Medica YZYong ZhangInner Mongolia Agricultural University ZDZhimin DuHarbin Medical University

Discussion

Member takes

Implication

Choline may preserve myocyte gap-junction integrity during ischemia; hypothesis-generating in animals and leaves open clinical translation.

Structured PICO

Population

Ventricular myocytes from control and ischemic hearts

Intervention

Ischemia (with and without choline administration prior to ischemia)

Comparator

Control (non-ischemic) conditions

Outcome

Expression and association of connexin 43 and M2/M3 acetylcholine muscarinic receptorssurrogate

Ischemia disrupts the interaction between connexin 43 and M3-mAChR in ventricular myocytes, an effect that can be partially prevented by choline administration.

Cite This Study

Yue et al. (2006) studied this question.

synapsesocial.com/papers/6a8fbdf16f3c76376440c1cd https://doi.org/10.1159/000092074

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Implication

Choline may preserve myocyte gap-junction integrity during ischemia; hypothesis-generating in animals and leaves open clinical translation.

Ischemia Impairs the Association Between Connexin 43 and M3 Subtype of Acetylcholine Muscarinic Receptor (M3-mAChR) in Ventricular Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ischemia Impairs the Association Between Connexin 43 and M3 Subtype of Acetylcholine Muscarinic Receptor (M3-mAChR) in Ventricular Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider