November 14, 2001The FASEB Journal

Chronic effects of endothelin‐1 and angiotensin‐II on gap junctions and intercellular communication in cardiac cells

View Full Paper

Ask AI

Bookmark

Population

Cultured neonatal rat ventricular cardiomyocytes (NRCs)

Comparison

Incubation with Endothelin-1 or angiotensin-II… vs Untreated cells or cells treated with receptor…

Design

Preclinical

Follow-up

24 h

Authors

LPLioudmila PolontchoukHalle Institute for Economic Research BEBerit EbeltLuther University MJMiriam JackelsUniversity of Cologne

Discussion

Member takes

Implication

Does not support clinical translation yet; hypothesis-generating for ET-1/AT-II effects on cardiac gap junctions.

Structured PICO

Population

Cultured neonatal rat ventricular cardiomyocytes (NRCs)

Intervention

Incubation with Endothelin-1 (ET-1) or angiotensin-II (AT-II) at concentrations ranging from 10 to 1000 nM for 24 h

Comparator

Untreated cells or cells treated with receptor antagonists (BQ123, BQ788, losartan) or MAPK inhibitors

Outcome

Expression and phosphorylation of connexin43 (Cx43) and connexin40 (Cx40), and gap junctional conductancesurrogate

ET-1 and AT-II upregulate Cx43 expression and gap junctional communication in neonatal rat cardiomyocytes via specific receptor and MAPK signaling pathways.

Cite This Study

Polontchouk et al. (2001) studied this question.

synapsesocial.com/papers/6a74dfb60081fe7b05dbf0aa https://doi.org/10.1096/fj.01-0381fje

View Full Paper

Ask AI

Bookmark

Chronic effects of endothelin‐1 and angiotensin‐II on gap junctions and intercellular communication in cardiac cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Chronic effects of endothelin‐1 and angiotensin‐II on gap junctions and intercellular communication in cardiac cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider