Population
Human cardiac tissue obtained from open-heart surgery (n=6)
Comparison
Angiotensin II alone or co-incubated with… vs Absence of Angiotensin II
Design
Preclinical
Follow-up
24 hours
Authors
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AT1 blockade may suppress Ang II-driven MAPK signaling in cardiomyocytes; leaves open whether AT2 modulation warrants clinical investigation.
Angiotensin II stimulates ERK and p38 MAPK activities in human cardiomyocytes primarily through AT1-receptors, with modulation by AT2-receptors.
Wei et al. (2000) studied this question.
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