Key result
ANG II activation of MKP-1 in adult rat ventricular myocytes was mediated by AT2-receptor activation, demonstrating constitutive and inducible suppression of ERKs by MKP and PP-2A/PP-1.
Population
Adult rat ventricular myocytes (ARVM) and cardiac microvascular endothelial cells (CMEC)
Design
Preclinical
Authors
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No immediate clinical implications from rat data; extends AT2-mediated ERK suppression mechanisms for further study.
In adult rat ventricular myocytes, ANG II activates MKP-1 via AT2 receptors, demonstrating constitutive and inducible suppression of ERKs by MKP and PP-2A/PP-1.
Fischer et al. (1998) studied this question. ANG II was evaluated on ERK activity and MKP-1 mRNA levels. ANG II activation of MKP-1 in adult rat ventricular myocytes was mediated by AT2-receptor activation, demonstrating constitutive and inducible suppression of ERKs by MKP and PP-2A/PP-1.
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