Key result
In neonatal rat ventricular cardiomyocytes, the trophic effects of Angiotensin II are mediated via local Endothelin-1 secretion upon AT1-receptor stimulation in non-myocyte cells.
Population
Neonatal rat ventricular cardiomyocytes and non-myocyte cells
Comparison
Angiotensin II and endothelin-1 with various… vs Basal conditions (untreated cells)
Design
Preclinical
Authors
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Does not inform clinical practice; leaves open ET-1 mediation of Ang II effects in adult human cardiomyocytes.
The trophic effects of Angiotensin II on neonatal rat ventricular cardiomyocytes are mediated via local endothelin-1 secretion from non-myocyte cells upon AT1-receptor stimulation.
Pönicke et al. (1997) studied Neonatal rat cardiomyocytes (in vitro). Angiotensin II and Endothelin-1 vs. Basal / receptor antagonists (bosentan, BQ-123, IRL 1038, losartan) was evaluated on Inositol phosphate (IP)-formation and rate of protein synthesis ([3H]-phenylalanine incorporation). In neonatal rat ventricular cardiomyocytes, the trophic effects of Angiotensin II are mediated via local Endothelin-1 secretion upon AT1-receptor stimulation in non-myocyte cells.
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