Key result
Angiotensin II produced concentration-dependent increases in cytosolic free calcium in neonatal rat cardiomyocytes, which were blocked by the AT1 receptor antagonist losartan but not PD 123319.
Angiotensin II increases cytosolic calcium in neonatal rat cardiomyocytes exclusively via the AT1 receptor subtype.
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Should not change practice; supports AT1 exclusivity in neonatal rat cardiomyocyte calcium signaling.
Touyz et al. (1996) studied this question. Angiotensin II vs. Losartan or PD 123319 was evaluated on Cytosolic free calcium concentrations ([Ca2+]i). Angiotensin II produced concentration-dependent increases in cytosolic free calcium in neonatal rat cardiomyocytes, which were blocked by the AT1 receptor antagonist losartan but not PD 123319.
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