Why the study?
Does Angiotensin II stimulate calcium signaling in vascular smooth muscle cells lacking AT1A receptors?
Population
Cultured aortic vascular smooth muscle cells from angiotensin II receptor subtype 1A knockout mice and…
Comparison
Angiotensin II exposure, with or without AT2… vs Wild-type VSMCs
Design
Preclinical
Authors
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Losartan-sensitive Ang II calcium signaling persists without AT1A; leaves open AT1B contribution to human vascular responses.
Does Angiotensin II stimulate calcium signaling in vascular smooth muscle cells lacking AT1A receptors?
Angiotensin II causes calcium signaling in AT1A-deficient vascular smooth muscle cells mediated by an endogenous losartan-sensitive AT1B receptor.
Zhu et al. (1998) studied this question.
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