Population
Cultured neonatal rat ventricular myocytes
Comparison
Angiotensin II (10(-8) M) vs Control basal state
Design
Preclinical
Authors
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No immediate clinical implications from neonatal rat cells; leaves open ANG II effects on human cardiomyocyte calcium handling.
Angiotensin II produces an acute rise in cytosolic free calcium in neonatal rat cardiomyocytes, predominantly derived from sarcoplasmic reticulum stores, followed by a reduction in calcium transient amplitude.
Kem et al. (1991) studied this question.
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