Key result
Intracellular administration of angiotensin II reduced the peak inward calcium current by 35% in adult rat ventricular myocytes (P<0.05) but increased it by 36% in hamster myocytes.
Population
Single ventricular myocytes isolated from adult rat ventricle and Golden hamsters
Design
Preclinical
Authors
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Species-specific calcium current effects caution against rodent-to-human extrapolation; leaves open intracellular angiotensin II mechanisms in human myocardium.
p-value: p=<0.05
Intracellular angiotensin II regulates inward calcium current and myocardial contractility in a species-dependent manner, independent of surface AT1 receptors.
Walmor C. De Mello (1998) studied this question. Intracellular angiotensin II was evaluated on Peak inward calcium current (ICa) (p=<0.05). Intracellular administration of angiotensin II reduced the peak inward calcium current by 35% in adult rat ventricular myocytes (P<0.05) but increased it by 36% in hamster myocytes.