Population
Cardiomyocytes isolated from cardiomyopathic hamsters and control animals
Comparison
Extracellular and intracellular administration… vs Baseline/control conditions without Angiotensin…
Design
Preclinical
Authors
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Ang II effects on I(Ca) in failing hamster cardiomyocytes are hypothesis-generating; leaves open relevance to human heart failure.
Intracellular and extracellular angiotensin II modulate L-type calcium currents in the failing heart, suggesting endogenous Ang II contributes to calcium handling alterations in cardiomyopathy.
Mello et al. (2004) studied this question.
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