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Three at a time: Sequential carbonyl addition, chelation-controlled conjugate addition, and alkylation triggers the multicomponent assembly of diverse nitriles. The chelation-controlled conjugate addition–alkylation installs three new stereocenters (see scheme), thereby generating substituted nitriles that are ideal terpenoid precursors as illustrated in the synthesis of epi-dehydroabietic acid.
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Fleming et al. (2004) studied this question.
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