Population
Cultured human umbilical vein endothelial cells, human dermal microvascular endothelial cells, and bovine…
Design
Preclinical
Authors
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Endothelial vWF reductase activity may modulate hemostasis; leaves open enzyme identity, in vivo role, and therapeutic targeting.
Endothelial cells secrete a vWF reductase that reduces the size of vWF multimers by cleaving interchain disulfide bonds, which may regulate its haemostatic activity.
Xie et al. (2000) studied this question.
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