December 1, 2003

In vitro modulation of the multiple sclerosis (MS)-associated retrovirus by cytokines: implications for MS pathogenesis.

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Why the study?

Do cytokines modulate MSRV release in peripheral blood mononuclear cells from MSRV-positive individuals?

Population

Peripheral blood mononuclear cells from MSRV-positive and MSRV-negative individuals

Comparison

Cytokines vs Spontaneous release or MSRV-negative cells

Design

Preclinical

Authors

CSCaterina SerraUniversity of Pisa GMGiuseppe MameliApple (Israel)GAGiannina ArruUniversity of Sassari

Discussion

Member takes

Implication

Hypothesis-generating for cytokine-MSRV links in MS; leaves open in vivo relevance and clinical translation.

Structured PICO

Do cytokines modulate MSRV release in peripheral blood mononuclear cells from MSRV-positive individuals?

Population

Peripheral blood mononuclear cells from MSRV-positive and MSRV-negative individuals

Intervention

Cytokines (interleukin-4, interleukin-6, interferon gamma, tumor necrosis factor alpha, interferon beta)

Comparator

Spontaneous release (no cytokine addition) or MSRV-negative cells

Outcome

MSRV release/productionsurrogate

Cytokines involved in MS pathogenesis modulate MSRV release in vitro, with detrimental cytokines increasing and therapeutic interferon beta inhibiting virus production.

Cite This Study

Serra et al. (2003) studied this question.

synapsesocial.com/papers/6a8fce98196c2a753a08c6e2 https://doi.org/10.1080/13550280390246462

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Ask AI

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In vitro modulation of the multiple sclerosis (MS)-associated retrovirus by cytokines: implications for MS pathogenesis.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

In vitro modulation of the multiple sclerosis (MS)-associated retrovirus by cytokines: implications for MS pathogenesis.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider