Why the study?
Does the presence of CAD and T2DM impair the angiogenic activity of autologous adipose-derived stromal cells compared to healthy controls?
Population
79 patients, including 19 controls without established cardiovascular diseases and metabolic disorders, 32…
Comparison
In vitro analysis of adipose-derived stromal… vs ADSC from control patients without established…
Design
Preclinical
Authors
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Impaired ADSC angiogenesis in CAD/T2DM cautions against autologous therapy assumptions; hypothesis-generating for PAI-1 modulation in future cell-therapy trials.
Does the presence of CAD and T2DM impair the angiogenic activity of autologous adipose-derived stromal cells compared to healthy controls?
Adipose-derived stromal cells from patients with CAD and T2DM exhibit impaired angiogenic activity, likely due to increased secretion of PAI-1, which may limit the efficacy of autologous cell therapy in these populations.
Dzhoyashvili et al. (2014) studied this question.
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