What question did this study set out to answer?

To elucidate the organizing principles, biological micro-architecture, and functional consequences of brain network dynamic alterations caused by neuromodulation and focal brain lesions.

March 1, 2025Fundamental ResearchOpen Access

Transcranial direct current stimulation and lesions hierarchically reorganize brain network dynamics with biological annotations

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Authors

JCJie ChenShandong University of Technology FWFeixue WangNational University of Defense Technology LZLei ZhaoChina Agricultural University

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Implication

Neuroimaging study reveals that brain stimulation and lesions hierarchically alter network dynamics, highlighting micro-architectural constraints on cortical plasticity.

Key Points

To elucidate the organizing principles, biological micro-architecture, and functional consequences of brain network dynamic alterations caused by neuromodulation and focal brain lesions.
Analyzed large-scale functional magnetic resonance imaging (fMRI) datasets using focal perturbation approaches to modulate brain network dynamics across prefrontal and motor cortices.
Mapped dynamic network reorganization against multi-scale biological profiles, including neurotransmitter receptor and transporter distributions, cell types, cortical expansion, and metabolism.
Evaluated the association between altered dynamic network patterns in bilateral motor regions and behavioral motor deficits in patients with brain lesions.
Perturbations of the prefrontal versus motor cortices triggered opposing topographic shifts in network dynamics along the sensorimotor-association cortical hierarchy.
Network dynamic reorganizations spatially co-localized with underlying micro-architectural profiles, with the strongest alignment observed for neurotransmitter systems.
Altered dynamic network activity within bilateral motor regions significantly tracked motor performance impairment in lesion patients.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/6a8fd70ee379aceceb3d9baf https://doi.org/10.1016/j.fmre.2025.02.017

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Implication

Neuroimaging study reveals that brain stimulation and lesions hierarchically alter network dynamics, highlighting micro-architectural constraints on cortical plasticity.

Transcranial direct current stimulation and lesions hierarchically reorganize brain network dynamics with biological annotations

Discussion

Member takes

Implication

Key Points

Cite This Study

Transcranial direct current stimulation and lesions hierarchically reorganize brain network dynamics with biological annotations

Discussion

Member takes

Implication

Key Points

Cite This Study

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