This is the first reported case of amiodarone anaphylaxis confirmed by mast cell tryptase levels and skin testing.
Possible IV amiodarone anaphylaxis warrants consideration; single case leaves open standardization of tryptase and skin testing.
Amiodarone, a class III antiarrhythmic, has been widely used to treat both ventricular and supraventricular arrhythmias. Despite the multitude of side-effects seen with this drug, no case of amiodarone anaphylaxis (confirmed by mast cell tryptase levels and skin testing) has been reported in the medical literature. We report a case of anaphylaxis to intravenous amiodarone in a 77-year-old patient.
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Fransi et al. (2004) studied this question.
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