Why the study?
Does LPS pre-treatment or TLR4 deficiency reduce infarct size in a mouse model of myocardial ischaemia-reperfusion injury?
Population
Wild-type and TLR4-deficient mice undergoing 60 min left anterior descending artery occlusion
Comparison
Lipopolysaccharide stimulation 16 h ahead of LAD… vs PBS stimulation 16 h ahead of LAD ligation in…
Design
Preclinical
Follow-up
24 hours of reperfusion
Authors
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TLR4 modulation may limit infarct size in ischaemia-reperfusion; leaves open translation to human myocardial infarction.
Does LPS pre-treatment or TLR4 deficiency reduce infarct size in a mouse model of myocardial ischaemia-reperfusion injury?
TLR4 deficiency and LPS pre-treatment reduce myocardial infarct size following ischaemia-reperfusion injury in mice, independent of MMP/TIMP regulation.
Stapel et al. (2006) studied this question.
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