Deep Venous Thrombosis; Mean Platelet Volume, D-Dimer and Doppler Sonography. Patients of Surgical Wards of Liaquat University Hospital

Objectives: To study mean platelet volume (MPV) in deep venous thrombosis(DVT) as evaluated by D-Dimmer and Doppler sonography. Study Design: Case control study.Place and Duration: Department of Surgery, Liaquat University of Medical and Health SciencesJamshoro/Hyderabad from May 2013 to April 2014. Subjects and Methods: A sampleof 106 subjects; 50 controls and 53 diagnosed patients of DVT were studied. DVT patientswere included according to inclusion and exclusion criteria and after results of Sonographyand D-Dimer were available. The Blood samples were collected in bottles containing sodiumcitrate as anticoagulant. MPV was generated by Sysmex KX 21 hematology analyzer. Informedconsent was sought from the volunteer subjects. The Data was analyzed using SPSS version21.0. Statistically significance was defined at p-value of ≤0.05. Results: Mean plateletvolume was elevated in deep venous thrombosis patients which were confirmed by clinicalexamination, sonography and D-Dimer. MPV was elevated in cases; 10.0±0.7fl compared tocontrols; 9.55±0.63fl (p=0.001). D-Dimmer was elevated in deep venous thrombosis patients(p=0.0001). Age, gender and platelet counts did not revealed any significant differencesbetween cases and controls (p>0.0.05). Conclusion: The present study reports elevatedMPV in patients suffering from deep venous thrombosis and it is concluded that MPV may beconsidered as a risk factor for DVT