What does this research mean for the field?

In Spanish children, food protein-induced enterocolitis syndrome (FPIES) is predominantly an acute, mild-to-moderate condition triggered most frequently by a single food, primarily cow's milk, followed by hen's egg and fish. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To describe the clinical characteristics, food trigger profile, diagnostic pathways, and acute and long-term management of children with food protein-induced enterocolitis syndrome (FPIES) in Spain.

August 27, 2026Journal of Pediatric Gastroenterology and NutritionOpen Access

Food protein‐induced enterocolitis syndrome in Spanish children: Results from a multicentre prospective study

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Authors

SMS. Rodríguez ManchónServices Hospital BEBeatriz EspínHospital Universitario Virgen del Rocío ÓSÓscar SegarraVall d'Hebron Hospital Universitari

Discussion

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Implication

Prospective multicenter registry study reports cow's milk as the leading trigger for acute enterocolitis in infants, highlighting improved clinical awareness and shorter diagnostic delays.

Key Points

To describe the clinical characteristics, food trigger profile, diagnostic pathways, and acute and long-term management of children with food protein-induced enterocolitis syndrome (FPIES) in Spain.
Conducted a prospective multicenter registry study across Spain enrolling children born in 2019 (N=28) diagnosed with acute or chronic FPIES according to international consensus criteria.
Tracked clinical severity, trigger foods, diagnostic delays, the use of diagnostic oral food challenges, and dietary interventions.
Among 32 recorded episodes in 28 patients (64.3% male), 92.8% presented with acute mild-to-moderate severity, triggered by cow's milk (59.4%), hen's egg (15.6%), and fish (9.4%).
Onset occurred during exclusive breastfeeding in 31.6% (6/19) of cow's milk cases, while oral food challenge was used for diagnosis in 23.1% (6/26) of acute cases and 50.0% (1/2) of chronic cases.
Median diagnostic delay was 6.5 days (IQR 0.25–13.5), with management centered on intravenous hydration, ondansetron, and extensively hydrolyzed formulas.

Cite This Study

Manchón et al. (2026) studied this question.

synapsesocial.com/papers/6a8fe98110c91c1e926210bd https://doi.org/10.1002/jpn3.70547

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Implication

Prospective multicenter registry study reports cow's milk as the leading trigger for acute enterocolitis in infants, highlighting improved clinical awareness and shorter diagnostic delays.

Food protein‐induced enterocolitis syndrome in Spanish children: Results from a multicentre prospective study

Discussion

Member takes

Implication

Key Points

Cite This Study

Food protein‐induced enterocolitis syndrome in Spanish children: Results from a multicentre prospective study

Discussion

Member takes

Implication

Key Points

Cite This Study

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