In vitro comparative study demonstrates distinct structural features and antioxidant and hypoglycemic activities of dandelion root polysaccharides, indicating functional food potential.
The increasing demand for functional products has promoted research on bioactive compounds. Dandelion root polysaccharide (DRP), a key bioactive component of Taraxacum officinale, has anti-inflammatory, antioxidant, hypoglycemic and hypolipidemic activities. This study extracted DRP via microwave-assisted enzymatic extraction (MAEE) to obtain mDRP, and isolated acidic polysaccharide mDRP-1 (7.548 kDa) by column chromatography. HPLC showed that both contain six monosaccharides (Man, Rha, GalA, Glu, Gal, Ara) with different molar ratios. mDRP is heterogeneous (trace protein/nucleic acids, no triple helix, amorphous), while mDRP-1 has a triple-helical, semi-crystalline structure; both have characteristic polysaccharide peaks and pyranose rings, and rough, porous surfaces. mDRP had better thermal stability and significant concentration-dependent in vitro antioxidant and hypoglycaemic effects.
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Zhang et al. (2026) studied this question.
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