Anyone interested in understanding the functional organization of DNA sequences in isolated eukaryotic genes is faced with the problems that in most cases the transcriptional units are poorly defined and that the individual gene units contain much spacer DNA of unknown function. Although it is now possible to sequence any cloned eukaryotic gene by quite rapid methods (Sanger and Coulson 1975; Maxam and Gilbert 1977), the problem remains of how to distinguish between those sequences which are relevant to gene regulation and those which are not.
No takes yet. Share an insight, caveat, or question.
Kressmann et al. (1978) studied this question.