What does this research mean for the field?

A newly developed polylactic acid (PLA) composite filament incorporating mollusk shell-derived filler and gentamicin exhibits antibacterial activity, ion-mediated bioactivity, and favorable in vivo biocompatibility for 3D printing of bone scaffolds. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Develop and evaluate a multifunctional polylactic acid (PLA) composite filament incorporating biogenic calcium and gentamicin for 3D-printed bone regeneration scaffolds using a Quality by Design framework.

August 27, 2026PharmaceuticsOpen Access

Bioactive PLA Filament with Antibacterial and Ion-Releasing Properties for Additive Manufacturing of Bone Scaffolds: QbD-Guided Development

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Authors

AKAnastassiya KhrustalevaKaraganda Medical University AYAzamat YedrissovKaraganda Medical University DKD. P. KhrustalevKaraganda Medical University

Discussion

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Implication

Preclinical study demonstrates biocompatibility and antibacterial efficacy in rat models, highlighting a versatile 3D-printable composite filament for custom bone scaffolds.

Key Points

Develop and evaluate a multifunctional polylactic acid (PLA) composite filament incorporating biogenic calcium and gentamicin for 3D-printed bone regeneration scaffolds using a Quality by Design framework.
Fabricated PLA filaments containing 20 wt.% mollusk shell-derived calcium filler and 5 wt.% gentamicin using solvent-free melt extrusion guided by Quality by Design principles.
Evaluated filament printability, multi-ion release kinetics via ICP-AES, thermal and mechanical integrity, antibacterial inhibition zones against bacterial strains, and biocompatibility in a rat subcutaneous model.
Produced uniform 1.75 ± 0.05 mm filaments with continuous mineral distribution that demonstrated multi-element ion release (primarily calcium, with strontium, magnesium, phosphorus, manganese, and iron).
Demonstrated potent antibacterial activity with inhibition zones of approximately 20–21 mm against all tested bacterial strains.
Rat subcutaneous implantation showed superior early biocompatibility compared to TiLOOP, including faster resolution of inflammatory infiltrates and complete absence of foreign body giant cells by day 14.

Cite This Study

Khrustaleva et al. (2026) studied this question.

synapsesocial.com/papers/6a8fe9da10c91c1e92621d5b https://doi.org/10.3390/pharmaceutics18091055

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August 27, 2026PharmaceuticsOpen Access

Bioactive PLA Filament with Antibacterial and Ion-Releasing Properties for Additive Manufacturing of Bone Scaffolds: QbD-Guided Development

View Full Paper

Ask AI

Bookmark

Authors

AKAnastassiya KhrustalevaKaraganda Medical University AYAzamat YedrissovKaraganda Medical University DKD. P. KhrustalevKaraganda Medical University

Discussion

Member takes

Implication

Preclinical study demonstrates biocompatibility and antibacterial efficacy in rat models, highlighting a versatile 3D-printable composite filament for custom bone scaffolds.

Key Points

Develop and evaluate a multifunctional polylactic acid (PLA) composite filament incorporating biogenic calcium and gentamicin for 3D-printed bone regeneration scaffolds using a Quality by Design framework.
Fabricated PLA filaments containing 20 wt.% mollusk shell-derived calcium filler and 5 wt.% gentamicin using solvent-free melt extrusion guided by Quality by Design principles.
Evaluated filament printability, multi-ion release kinetics via ICP-AES, thermal and mechanical integrity, antibacterial inhibition zones against bacterial strains, and biocompatibility in a rat subcutaneous model.
Produced uniform 1.75 ± 0.05 mm filaments with continuous mineral distribution that demonstrated multi-element ion release (primarily calcium, with strontium, magnesium, phosphorus, manganese, and iron).
Demonstrated potent antibacterial activity with inhibition zones of approximately 20–21 mm against all tested bacterial strains.
Rat subcutaneous implantation showed superior early biocompatibility compared to TiLOOP, including faster resolution of inflammatory infiltrates and complete absence of foreign body giant cells by day 14.

Cite This Study

Khrustaleva et al. (2026) studied this question.

synapsesocial.com/papers/6a8fe9da10c91c1e92621d5b https://doi.org/10.3390/pharmaceutics18091055

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