What does this research mean for the field?

Psychological stress accelerates hepatocellular carcinoma progression by remodeling myeloid cell function through sympathetic and HPA axis signaling to create an immunosuppressive tumor microenvironment. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate how psychological stress regulates myeloid cell activity and fosters an immunosuppressive tumor microenvironment in hepatocellular carcinoma.

August 27, 2026Cancer ScienceOpen Access

Psychological Stress Promotes Tumor Growth in Hepatocellular Carcinoma Models Through Myeloid Signaling

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Authors

KOKeita OgawaShizuoka University TATakahiro AokiNational Center for Global Health and Medicine TKTatsuya KanekoOsaka Prefectural Toyonaka Support School

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Implication

Preclinical study demonstrates that psychological stress accelerates hepatocellular carcinoma growth in mice, indicating that neuroendocrine-driven myeloid remodeling promotes tumor immunosuppression.

Key Points

To investigate how psychological stress regulates myeloid cell activity and fosters an immunosuppressive tumor microenvironment in hepatocellular carcinoma.
Assessed the effects of restraint stress on tumor growth and neutrophil infiltration across male and female mouse models of hepatocellular carcinoma.
Performed single-cell transcriptomics and in vitro assays to evaluate macrophage-derived chemokine secretion and β2-adrenergic receptor signaling.
Analyzed bone marrow neutrophil reprogramming driven by hypothalamic–pituitary–adrenal axis activation and glucocorticoid receptor signaling.
Restraint stress markedly accelerated hepatocellular carcinoma progression across mouse sexes and strains, accompanied by elevated neutrophil infiltration and chemokine levels.
Stress-induced catecholamines activated macrophage β2-adrenergic receptor signaling to drive Cxcl2 expression.
Activation of the hypothalamic–pituitary–adrenal axis stimulated corticosterone- and glucocorticoid receptor–dependent reprogramming of bone marrow neutrophils into an immunosuppressive phenotype.

Cite This Study

Ogawa et al. (2026) studied this question.

synapsesocial.com/papers/6a8fe9da10c91c1e92621d9e https://doi.org/10.1111/cas.70517

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Psychological Stress Promotes Tumor Growth in Hepatocellular Carcinoma Models Through Myeloid Signaling

Discussion

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Implication

Key Points

Cite This Study

Psychological Stress Promotes Tumor Growth in Hepatocellular Carcinoma Models Through Myeloid Signaling

Discussion

Member takes

Implication

Key Points

Cite This Study

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