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Biochemical engineering study demonstrates cofactor-tethered fused-enzyme nanomachines in continuous-flow cascades, suggesting a sustainable approach to cofactor-autonomous biomanufacturing.
The Cover Feature places cofactor-tethered fused-enzyme nanomachines in the spotlight, connecting molecular-scale design with industrial-scale biocatalysis. The continuous-flow reactor represents the reliance of conventional redox enzyme cascades on freely diffusing, valuable nicotinamide cofactors, whereas the nanomachine strategy retains and recycles these cofactors to support cofactor-autonomous operation, advancing sustainable biomanufacturing. More information can be found in the Research Article by V. Sieber and co-workers (DOI: 10.1002/cssc.70914).
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Dsouza et al. (2026) studied this question.
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